Exogenous prostacyclin decreases vasoconstriction but not platelet thrombus deposition after arterial injury
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چکیده
منابع مشابه
Neutrophil implications in platelet deposition and vasoconstriction after deep arterial injury by angioplasty in pigs.
BACKGROUND Experimental studies in vitro suggest that neutrophils can modulate platelet function and vasomotor responses. In the present study, the interactions among neutrophils, platelets, and arterial responses to injury in vivo were assessed. METHODS AND RESULTS The acute thrombotic and vasomotor responses of porcine carotid arteries to balloon injury in vivo were evaluated in three group...
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Monocyte chemoattractant protein (MCP)-1 is upregulated in atherosclerotic plaques and in the media and intima of injured arteries. CC chemokine receptor 2 (CCR2) is the only known functional receptor for MCP-1. Mice deficient in MCP-1 or CCR2 have marked reductions in atherosclerosis. This study examines the effect of CCR2 deficiency in a murine model of femoral arterial injury. Four weeks aft...
متن کاملFlavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo.
BACKGROUND Flavone-8-acetic acid (FAA; [Flavonoid]), an adjuvant antitumor drug, inhibits ristocetin-induced aggregation of human platelets. The effect of FAA on platelet-dependent thrombosis was studied in vivo in the porcine carotid artery after deep arterial injury by balloon angioplasty. METHODS AND RESULTS (111)In-labeled autologous platelet and (125)I-labeled porcine fibrin(ogen) deposi...
متن کاملramadan fasting decreases body fat but not protein mass
conclusions ramadan fasting resulted in weight loss even it was only a temporary effect, as the weight was quickly regained within one month after fasting. the catabolism catabolic state, which is related to protein loss, was not triggered during ramadan fasting. further research is needed to evaluate the effects of weight loss during ramadan fasting in healthy individuals. results by the 28th ...
متن کاملEndothelium-Dependent Arterial Vasoconstriction After Balloon Angioplast
To determine whether balloon angioplasty can provoke arterial vasoconstriction independent of platelet aggregation and neurogenic input, we studied the spontaneous vasomotor effects of balloon dilatation in isolated, perfused whole-vessel segments of rabbit aorta and pig carotid artery. Freshly dissected rabbit thoracic aortas were mounted in a muscle bath-perfusion chamber, perfused with physi...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1993
ISSN: 0735-1097
DOI: 10.1016/0735-1097(93)90693-u